产品简称

affinity isolated antibody, buffered aqueous solution

NACRES

NA.41

抗体产品类型

primary antibodies

物种反应性

human

生物来源

goat

单抗克隆号

polyclonal

偶连

unconjugated

抗体应用

immunohistochemistry: suitable;indirect ELISA: suitable;western blot: suitable

免疫原基因信息

human ... PPP1R15A(23645)

免疫原蛋白记录号

O75807

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

一般描述

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) or growth arrest and DNA-damage-inducible 34 (GADD34) is the regulatory subunit of eukaryotic translation initiation factor 2 (eIF2α) phosphatase. It is expressed when there is a signal indicating endoplasmic reticulum stress. The PPP1R15A gene is localized on human chromosome 19q13.33.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免疫原

Peptide with sequence C-AAALDLSGRRG from the C Terminus of the protein sequence according to NP_055145.2.

生化/生理作用

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) recruits and regulates the α-subunit of protein phosphatase 1 (PP1). It functions as a stress marker. When there is depletion in amino acid levels in the cell, PPP1R15A is expressed in high concentrations. It regulates the mammalian target of rapamycin (mTOR) pathway and thereby boosts autophagy in macrophages. Studies have shown that PPP1R15A is expressed in the oligodendrocytes of patients suffering from Alzheimer’s disease.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.