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DeepBio得分:5567.2
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≥97% (titration)
24896726
NA.26
ligand binding assay: suitable
α-(Methylamino)isobutyric acid (MeAIB) has been used: •as a system A transport system inhibitor to perform inhibition experiments •as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices •as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine
α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.
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