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≥95% (HPLC)
329825891
NA.77
human ... PTGS1(5742), PTGS2(5743)
DMSO: 20 mg/mL, clear
Ibufenac is a non-steroidal anti-inflammatory drug (NSAID) analog of ibuprofen that was withdrawn for hepatotoxicity. It inhibits cyclooxygenases COX-1 and -2 activity with IC50 values of 17.4 and 13.1 μM, respectively and > 40 μM for 5-LOX. It has been used in studies of drug-induced hepatotoxicity.
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