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DeepBio得分:5567.2
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DMSO: 100 mg/mL
Anderson, M.O., et al. 2012. J. Med. Chem.55, 5942. Yao, C., et al. 2012. J. Am. Soc. Nephrol.23, 1210.
A cell-permeable triazolothienopyrimidine compound that acts as a reversible urea transporter B-selective inhibitor (IC50 = 10.3 and 25.1 nM against urea influx using human and mouse erythrocytes, respectively) by targeting a UT-B intracellular site in a urea-competitive manner, exhibiting little effect toward UT-A1, UT-A3, AQP1, CFTR, or TMEM16A channel activities. Shown to effectively decrease maximum urinary concentration and increase urination volume from antidiuretic dDAVP-treated wild-type, but not UT-B-/-, mice (300 µg/300 µl/mouse i.p.) in vivo.
Packaged under inert gas
Reversible: yes
Toxicity: Standard Handling (A)
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