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A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.
DMSO: 20 mg/mL
Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology40, 139.
A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
Packaged under inert gas
Reversible: no
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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