产品简称

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

产品线

Prestige Antibodies® Powered by Atlas Antibodies

抗体产品类型

primary antibodies

物种反应性

human

生物来源

rabbit

单抗克隆号

polyclonal

偶连

unconjugated

抗体应用

immunofluorescence: 0.25-2 μg/mL;immunohistochemistry: 1:50-1:200

免疫原基因信息

human ... SDK1(221935)

免疫原蛋白记录号

Q7Z5N4

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

免疫原

Protein sidekick-1 precursor recombinant protein epitope signature tag (PrEST)

生化/生理作用

SDK1 (Sidekick cell adhesion molecule 1) is a transmembrane, hemophilic adhesion protein belonging to the immunoglobulin superfamily. It is highly involved in the podocyte dedifferentiation and proliferation. During glomeruli infection, proliferated podocytes conjugate with each other and form clusters called glomerular pseudocrescents that fill an enlarged Bowman′s space. Study shows that up-regulated expression of SDK1 in HIV-1 transgenic podocytes may form podocyte cluster. It has been reported that malfuntioning of SDK1 may contribute in the HIV-associated nephropathy (HIVAN) pathogenesis. It is also actively associated with the slit diaphragm linker protein, MAGI-1. MAGI-1 helps SDK1 to interact with other podocyte proteins including synaptopodin, α-actinin-4, nephrin, JAM4, and β-catenin.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: •IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. •Protein array of 364 human reco