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≥98% (HPLC)
329825234
NA.77
H2O: ≥5 mg/mL at warmed to 60 °C
MC2050 hydrate may be used in cell signaling studies.
MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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