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affinity isolated antibody, buffered aqueous solution
NA.41
primary antibodies
human, mouse
chicken
polyclonal
unconjugated
western blot: suitable
human ... APAF1(317)
O14727
Solution in phosphate buffered saline containing 0.02% sodium azide.
Anti-APAF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Solution in phosphate buffered saline containing 0.02% sodium azide.
Recombinant apoptotic protease activating factor isoform d
Apoptotic protease activating factor 1 is a human homolog of C. elegans CED-4 gene and is a key regulator gene of apoptosis. It acts as a central component of the intrinsic pathway of apoptosis. Loss of APAF-1 expression is involved with chemorefractory malignant melanoma and neuronal cell differentiation. Over expression of this gene is related to an undifferentiated state in the testicular germ cell tumor (TGCT) pathway and is involved in carcinogenesis of germ cell tumors. APAF-1, when bound to cytochrome c, may trigger the activation of caspase-3 leading to apoptosis.
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