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A 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
Ira, G., et al. 2004. Nature431, 1011. Papa, F.R., et al. 2003. Science302, 1533. Bishop, A.C., et al. 2000. Nature407, 395. Weiss, E.L., et al. 2000. Nat. Cell Biol.2, 677. Bishop, A.C., et al. 1999. J. Am. Chem. Soc.121, 627.
A cell-permeable and reversible PP1 analog (>Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC₅₀ = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
A 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
Packaged under inert gas
Target IC₅₀: 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
Toxicity: Irritant (B)
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