常用商品分类
服务电话(移)：17319309550
DeepBio得分:5567.2
DeepBio得分
是基于文献引用次数，影响因子，文献新近度等因素计算的客观产品评级，得分越高表明该产品经过越可靠的实验验证，质量可信度越高
DMSO: 10 mg/mL
Liu, Q., et al. 2011. J Med Chem.54, 1473. Liu, Q., et al. 2010, J Biol Chem.284, 8023.
A Torin1 (Cat. No. 475991) structural analog that acts as a cell-permeable, potent, ATP-competitive inhibitor against DNA-PK and mTOR (IC₅₀ = 0.5 and 2.81 nM, respectively). Comparing to Torin1, Torin2 displays enhanced inhibitory potency against PI 4-Kβ (IC₅₀ = 18.3 nM) and PI 3-K (IC₅₀ =4.68, 5.67, 8.58, 17.5, 24.5, and 28.1 nM, respectively, against P110α/P85α, P110γ, hVPS34, P110δ/P85α, C2β, C2α, respectively), while being more effective in inhibiting S6K1 Thr389 phosphorylation in MEF cultures (IC₅₀ = 0.25 nM vs 2 nM, respectively, for Torin2 and Torin1) in vitro and displaying much improved oral bioavailability in mice (Cₘₐₓ (ng/mL) /T1/2 (h) = 3968/0.72 and 223/0.79, respectively, for Torin2 and Torin1; 10 /mg/kg p.o.) in vivo.
Packaged under inert gas
Reversible: yes
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity: Standard Handling (A)
| 好评度 | 商品满意度 | 服务满意度 | 发货满意度 |
"475992-10MG，mTOR Inhibitor XII, Torin2"商品可能已被商家删除，您可查看其他相似商品！
相似产品推荐
购物车（0）
分类纠错
举报
纠错
收 藏
比价
线下结算
公务卡
网银支付
微信
支付宝