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The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
water: 1 mg/mL;DMSO: 5 mg/mL
Supplied as a trifluoroacetate salt.
Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163. Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.
A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC₅₀ = 50 nM). The inhibition is competitive with respect to the peptide substrate (Kᵢ = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
Supplied as a trifluoroacetate salt.
Packaged under inert gas
Target IC₅₀: 50 nM against MLCK
H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity: Standard Handling (A)
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