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DeepBio得分:5567.2
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A cell-permeable pyridyl methylsulfinyl benzimidazole compound that acts as selective proton pump inhibitor.
DMSO: 25 mg/mL
Lambrecht, N., et al. 2000. J. Biol. Chem.275, 4041. Besancon, M., et al. 1997. J. Biol. Chem.272, 22438. Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol.35, 277. Diaz, D., et al. 1990. Gastroenterology99, 737. Fellenius, E., et al. 1981. Nature290, 159.
A cell-permeable, selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H⁺-K⁺)-ATPase in the gastric milieu. Also acts as an aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.
Packaged under inert gas
Reversible: no
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity: Irritant (B)
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