产品简称

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii.

溶解度

water: 5 mg/mL

外形

Supplied as a trifluoroacetate salt.

其他说明

Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235. Liz, S.Z., et al. 1997. Brain Res.771, 184. Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217. Langel, U., et al. 1996. Regul. Peptides 62, 47. Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923. Igarashi, M., et al. 1993. Science259, 77. Komatsu, M., et al. 1992. Endocrinology130, 221. Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun.179, 852. Gil, J., et al. 1991. J. Cell Biol. 113, 943.

一般描述

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gᵢ and Gₒ rather than Gₛ. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca²⁺. Acts as a calmodulin antagonist and activates phospholipase A₂. Causes a transient Ca²⁺ release from the sarcoplasmic reticulum. Also reported to inhibit Na⁺,K⁺-ATPase activity (IC₅₀ = 7.5 µM).

外形

Supplied as a trifluoroacetate salt.

包装

Yes

生化/生理作用

Reversible: no

序列

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

警告

Toxicity: Standard Handling (A)