抗体产品类型

primary antibodies

物种反应性

rat, mouse, human

生物来源

rabbit

单抗克隆号

polyclonal

抗体应用

western blot: 1:20-1:100

免疫原基因信息

human ... CDKN1A(1026)

免疫原蛋白记录号

P38936

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

一般描述

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human P21 (NP_001207707.1).

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.