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The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
DMSO: 5 mg/mL
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC₅₀ = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Packaged under inert gas
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity: Standard Handling (A)
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