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DeepBio得分:5567.2
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The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
ethanol: 10 mg/mL;DMSO: 25 mg/mL
Costi, R., et al. 2007. J. Med. Chem.50, 1973.
A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤40 µM) and induce chromatin condensation in HeLa cells.
Packaged under inert gas
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
Toxicity: Standard Handling (A)
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