产品简称

IgG fraction of antiserum, buffered aqueous solution

NACRES

NA.46

抗体产品类型

primary antibodies

物种反应性

human

生物来源

rabbit

单抗克隆号

polyclonal

偶连

unconjugated

抗体应用

western blot: 1:500

免疫原基因信息

human ... PROC(5624)

免疫原蛋白记录号

P04070

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

应用

Anti-Protein C antibody produced in rabbit has been used to study the effects of zirconia-based stationary phase on its activity.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

一般描述

Protein C is synthesized by liver parenchymal cells as a single chain polypeptide, but in plasma, it consists mainly of a heavy chain (41 kDa) linked by a disulfide bond to a light chain (21 kDa). The plasma concentration of protein C is ~ 4 mg/mL with a half-life of about 15 hours.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免疫原

Protein C from human plasma.

生化/生理作用

Protein C is a vitamin K-dependent plasma zymogen which plays an essential role in the regulation of blood coagulation. Activated protein C also enhances fibrinolysis by forming a complex with plasminogen activator inhibitor, thus allowing enhanced activity of plasminogen activator. Hereditary and acquired protein C deficiency states have been recognized to be associated with thrombosis. Homozygous severe protein C deficiency manifests in the new born by massive thrombosis and purpura fulminans. Heterozygotes for this entity usually do not manifest thrombosis.

特异性

Specifically reacts with protein C in normal pooled human plasma and shows no reaction with protein C-depleted plasma.