产品简称

affinity isolated antibody, buffered aqueous solution

NACRES

NA.41

抗体产品类型

primary antibodies

物种反应性

human

生物来源

rabbit

单抗克隆号

polyclonal

偶连

unconjugated

抗体应用

immunocytochemistry: suitable;immunofluorescence: suitable;indirect ELISA: suitable;western blot: suitable

免疫原基因信息

human ... SCARA5(286133)

免疫原蛋白记录号

Q6ZMJ2

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

一般描述

The gene SCARA5 (scavenger receptor class A member 5) is mapped to human chromosome 8p21. It belongs to the SCARA family of proteins.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免疫原

SCARA5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SCARA5.

生化/生理作用

SCARA5 (scavenger receptor class A member 5) is a tumor suppressor. It plays an important role in growth regulation. It interacts with serum ferritin and helps it in crossing the blood-retinal barrier. Changes in the expression of SCARA5 are linked with retinopathy. It might also be involved in the suppression of inflammatory fibrotic responses.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

联系

The action of this antibody can be blocked using blocking peptide SBP3500071.

目标描述

Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains that collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery. At least four isoforms of SCARB1 are known to exist.